Implementation of a Novel Automated Sampling System for High Density Cell Culture Processes

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Manual bioreactor sampling is the primary cause for cell culture contamination and one of the main cost drivers in terms of man-hours required to execute this repetitive task. In addition, manual sampling increases offline measurement variability due to analysis delay and sample degassing. Several autosampler systems have been developed to facilitate the sampling process, but, many have struggled to demonstrate a high-level of sterility control, prevention of blockages at high cell densities and sample integrity on the way to the destination. Thus, our aim was to implement a new automated sampling system, BioProfile FLEX2 Autosampler, to improve process robustness and reduce manual handling on the bioreactor for long-term high density perfusion cell cultures.

Featured Presenter: Patrick Romann

Patrick Romann earned his Bachelor’s degree in Biochemistry at the University of Zurich and his trinational Master’s Degree in Biotechnology at the University of Strasburg (FR), University of Freiburg (DE) and the University of Basel (CH). Afterwards, he worked at Lonza Slough (UK) performing mass transfer studies to improve high density cell cultures. Two years ago, Patrick entered the PhD program at the University of Applied Sciences and Arts Northwestern Switzerland and the Vienna University of Technology

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Contact: Marit Hoppe