Produkter

For detection of Protein:Protein Interactions in Live Cells

NanoBRET Target Engagement Intracellular BET BRD Assay measures compound binding at select BET bromodomain target proteins within intact cells. The assay is based on NanoBRET, an energy transfer technique for measuring molecular proximity in living cells.

NanoBRET Target Engagement Intracellular HDAC Assay measures compound binding at select HDAC target proteins within intact cells. The assay is based on NanoBRET System, an energy transfer technique designed to measure molecular proximity in living cells.

The NanoBRET Target Engagement (TE) Assay measures compound binding at select kinase targets within intact cells. The assay is based on the NanoBRET System, an energy transfer technique designed to measure molecular proximity in living cells.

The NanoBRET Target Engagement (TE) Assay measures compound binding at select kinase targets within intact cells. The assay is based on the NanoBRET System, an energy transfer technique designed to measure molecular proximity in living cells.

NanoBRET™ assay technology is dependent upon energy transfer from a luminescent donor (NanoLuc® luciferase) to a fluorescent acceptor (HaloTag® NanoBRET™ 618 Ligand). NanoLuc® luciferase HaloTag® protein are fused to the target proteins of interest and fusion proteins expressed at low cellular levels, enabling monitoring and screening studies of protein interactions that reflect true cellular physiology. The NanoBRET™ Assay is fully reversible, enabling studies of both induction and inhibition of protein interactions. 

Sensitive Detection of Protein Interactions in Live Cells

Transfection-ready DNA to express full-length BMP2K kinase fused to NanoLuc® luciferase